Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin.
نویسندگان
چکیده
The synthesis of β-thiolactone and β-lactam analogs of tetrahydrolipstatin is described from a common late-stage β-lactone derivative. These analogs, and a cis-disubstituted β-lactone analog of tetrahydrolipstatin, were screened for activity against porcine pancreatic lipase and for inhibition of cell growth of a panel of four human cancer lines.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 13 شماره
صفحات -
تاریخ انتشار 2012